cast
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Brendan Fraser
Stu Miley
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Bridget Fonda
Dr. Julie McElroy
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John Turturro
Monkeybone (voice)
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Chris Kattan
Organ Donor Stu
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Giancarlo Esposito
Hypnos
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Rose McGowan
Miss Kitty
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Dave Foley
Herb
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Megan Mullally
Kimmy Miley
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Bob Odenkirk
Head Surgeon
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Whoopi Goldberg
Death
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Pat Kilbane
Burger God Representative
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Lisa Zane
Medusa
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Sandra Thigpen
Alice
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Wayne Wilderson
Hutch
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Amy Higgins
Clarissa
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Alan Gelfant
Dr. Edelstein
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Kristin Norton
Nurse
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Chris Hogan
Bill, Bazoom Toy Representative
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Lucy Butler
Guest
- John Sylvain Ambulance Driver
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Lou Romano
Cop / Psycharist
- Leon Laderach Surgeon in Nightmare
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Scott Rogers
Surgeon
- Cris Thomas-Palomino Surgeon
- Tony Panterra Surgeon
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Ted Rooney
Grim Reaper (voice)
- Christopher Franciosa Reaper Who Takes Lulu
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Mary Stein
Lulu
- Fred Pierce Reaper in Death's Office
- Harper Roisman Earl Biegler
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Kristopher Logan
Patron
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Scott Workman
Arnold the Super Reaper
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Shawnee Free Jones
Lizzie Borden
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Ilia Volok
Rasputin
- Edgar Allan Poe IV Edgar Allan Poe
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Claudette Mink
Typhoid Mary
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Jon Bruno
Man in the Dungeon / Stephen King
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Owen Masterson
Jack the Ripper
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Jen Sung
Attila the Hun
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Tracy Zahoryin
Model
- Sunshine Deia Tutt Model
- Jo Haugen Gash Model
- Lindsay Bryan Model
- Brooke Boisse Model
- Meron Abebe Model
- Mie Kringelbach Model
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Rex Reddick
Museum Guard / Tuxedo Guard
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Sybil Azur
Museum Dancer
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Anne Fletcher
Museum Dancer
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Diane Mizota
Museum Dancer
- Etty Lau All-Girl Band Sax Player
- LaTonya Holmes All-Girl Band Percussionist
- Lesli Jean Matta All-Girl Band Drummer
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Dawn Solér
All-Girl Band Member
- Miko Watanbe All-Girl Band Member
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Frankie Pine
All-Girl Band Member
- Anne King All-Girl Band Member
- Rachen Assapiomonwait Korean Father
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Veena Bidasha
Statue Woman
- Michael Anthony Jackson Bug Man
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Doug Jones
Yeti
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Arturo Gil
Rat Guard
- Jody St. Michael Centaur
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Brian Steele
Jumbo the Elephant God
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Leif Tilden
Cyclops
- Tom Fisher Community Service Cigarette Sweeper
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Joseph S. Griffo
BBQ Pig
- Kim Timbers-Patteri Wasp Woman
- Lisa Ebeyer Betty the Bovine
- Mark Viniello Assbackward
- Nathan Stein Sea Monster
- Ed Holmes Buffalo Kuchina
- Erica Gudis Party Babe Hybrid #1
- Melinda Miamor Party Babe Hybrid #2
- Caroline A. Rice Party Babe Hybrid #3
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Joe Ranft
Streetsquash Rabbit (voice)
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Bruce Lanoil
Streetsquash Raccoon (voice)
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Debi Durst
Streetsquash Snake (voice)
- Phil Brotherton Subramansa (voice)
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Roger L. Jackson
Arnold the Super Reaper (voice)
- Jym Dingler Community Service Cigarette Sweeper (voice)
- Leslie Hedger Assbackward (voice)
- Toby Gleason Buffalo Kachina (voice)
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Allan Trautman
BBQ Pig (voice)
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Mike Mitchell
Miss Hudiapp (voice)
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Randall Bosley
Fred
- Brendan Burns Detective #1
- Robert 'Duckie' Carpenter Record Store Owner / Coma Victim
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Thomas Haden Church
Death's Assistant
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Jamie Donovan
Reporter #1
- Roger Ferreira Visitor
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Wendy Fowler
Beautiful Fan
- Paul Guiles Reporter #2
- Harry Jay Knowles Lucky
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Jason Kravits
Guest
- Skyler Marshall Janitor
- George Meyers Bazoom Toy Rep
- Michelle Shaffer Woman with Bat
- Tom Tangen Burger God Representative