cast
-
Andrew Rannells
Matthew MacDell (voice) / Matthew (voice)
-
Nick Kroll
Nick Birch / Maury the Hormone Monster / Coach Steve (voice)
-
John Mulaney
Andrew Glouberman (voice)
-
Jessi Klein
Jessi Glaser (voice)
-
Jason Mantzoukas
Jay Bilzerian (voice)
-
Maya Rudolph
Diane Birch / Connie the Hormone Monstress (voice)
-
Fred Armisen
Elliot Birch (voice)
-
Jordan Peele
Ghost of Duke Ellington (voice)
-
Jenny Slate
Missy Foreman-Greenwald (voice)
-
Joe Wengert
Caleb (voice) / Caleb / Lump Humpman (voice) / Caleb / Rewind Shirt Kid / Go-Gurt Burglar (voice) / Stan the Hormone Monster / Ambition Gremlin (voice) / Caleb / IUD (voice) / Caleb / Go-Gurt Burglar (voice) / Caleb / Pornscape Residents (voice) / Caleb / Go-Gurt Thief / Teacher (voice) / Caleb / Dot #3 / Leore Paulblart (voice) / Teacher (voice) / Mr. Albert (voice) / Steven Tyler Glade Plug-In / Zombie (voice)
-
Ayo Edebiri
Missy Foreman-Greenwald (voice) / Missy Foreman-Greenwald / Mosaic Missy (voice)
-
June Diane Raphael
Devin (voice)
-
Richard Kind
Marty Glouberman (voice)
-
Jessica Chaffin
Shannon Glaser (voice) / Shannon Glaser / Grace / Intellect Sphinx (voice)
-
Neil Casey
Lars (voice) / Detective Dumont / D.N. Ape (voice) / (voice) / Lars / Jew Penis (voice) / Lars / Rewind Shirt Kid (voice) / Lars / Detective Dumont (voice) / Detective Dumont / Lars (voice) / Lars / Boy (voice) / Lars / Detective Dumont / Pornscape Residents (voice) / Detective Dumont (voice)
-
Paula Pell
Barbara Glouberman (voice) / (voice) / Barbara Glouberman / Lola's Couch Pillow (voice) / Barbara Glouberman / Bubbe (voice)
-
Jon Daly
Judd Birch (voice) / Garrison Keillor / Magician #1 (voice) / Judd Birch / Pumbaa (voice)
-
Jak Knight
DeVon (voice) / Tall Guy (voice) / DeVon / DeVon / Gina's Brother #2 (voice)
-
Chelsea Peretti
Monica Foreman-Greenwald (voice) / Cellsea (voice) / Diaphragm (voice)
-
Seth Morris
Greg Glaser (voice) / (voice) / Ninth Grader (voice)
-
Gil Ozeri
Wiggles (voice) / (voice) / Brad (voice) / Jew Fishman (voice) / Man #1 / Dot #2 (voice) / The Ponytail Killer / Pornscape Residents (voice)
- Mark Rivers (voice) / Ghost of David Bowie (voice) / Man #2 / Penis Worms (voice) / Siamese Twin #1 (voice) / Vendor (voice) / Michael Stipe Tampon (voice) / Maury's Backup Singer (voice) / Backup Singer (voice)
-
Nathan Fillion
Nathan Fillion (voice)
-
Kat Dennings
Leah Birch (voice) / Leah Birch / Lorraine the Hormone Monstress (voice)
-
Gina Rodriguez
Gina Alvarez (voice) / Gina Alvarez / Gina Parrot (voice)
-
David Thewlis
Shame Wizard (voice)
-
Thandiwe Newton
Mona (voice)
-
Brandon Kyle Goodman
Walter the Lovebug (voice) / Walter (voice)
-
Maria Bamford
Tito the Anxiety Mosquito (voice)
-
Heather Lawless
Jenna Bilzerian (voice)
-
Mark Duplass
Val Bilzerian (voice)
-
Whitmer Thomas
-
Paul Scheer
Kurt Bilzerian (voice)
-
Ali Wong
Ali (voice)
-
Zachary Quinto
Aiden (voice)
-
Stephanie Beatriz
Lulu (voice)
- Emily Altman Vicky (voice) / Milk (voice) / Olivia / Filmstrip Narrator (voice) / (voice)
-
Chloe Fineman
Leah Birch (voice)
-
Rob Huebel
Mr. Lizer (voice)
-
Natasha Lyonne
Suzette (voice) / Ms. Dunn (voice)
-
Gary Cole
Andrew's Father (voice) / Edward MacDell (voice) / Matthew's Father (voice)
-
Jean Smart
Depression Kitty (voice)
-
Jack McBrayer
Pubic Hair #1 (voice) / Jack (voice)
-
John Gemberling
Tyler the Hormone Monster (voice) / Tyler the Hormone Monster / Dot #1 (voice) / Security Guard / Bus Driver's Son (voice)
-
Craig Robinson
Pubic Hair #2 (voice) / Craig (voice) / Harvey Brooks (voice) / End Credits Singer (voice)
-
Michaela Watkins
Cantor Dina Reznick (voice)
-
Fran Gillespie
(voice) / Girl (voice) / Samira (voice) / Maddie the American Girl Doll / Choir Girl (voice)
-
Kristen Bell
Pam the Pillow (voice) / Uninterested Girl (voice)
- Ashley London Kitty / DNA Expert / Pornscape Residents (voice) / Skank (voice) / The Virgin Mary / Waitress (voice) / (voice)
-
Zach Woods
Daniel (voice) / Sock (voice)
-
Rosa Salazar
Ms. Benitez (voice)
-
Quinta Brunson
Quinta (voice) / Girl (voice)
-
Ayden Mayeri
Gabrielle (voice) / Gabrielle / Freshman (voice) / Gabrielle / Sad Boy #2 (voice) / Gabrielle / Mellon Ball / Honeydew (voice)
-
Andy Daly
Dr. Wendy Engle / Motel Pillow #1 (voice) / Dr. Wendy Engle (voice) / Ghost of Harry Houdini (voice)
-
Bobby Cannavale
Nick's Agent (voice) / Gavin the Hormone Monster (voice) / Gavin (voice)
-
John Oliver
Harry (voice)
-
Seth Rogen
Seth Goldberg (voice)
-
Julie White
Kimberly (voice) / Kimberly MacDell (voice)
-
Sterling K. Brown
Michael Angelo (voice)
- Crissy Guerrero (voice)
-
Kristen Wiig
Jessi's Vagina (voice)
-
Lena Waithe
Lena (voice)
-
Megan Thee Stallion
Megan the(e?) Hormone Monstress (voice)
-
Patrick Page
Dread (voice)
- Ileen Goldsmith (voice) / Jessi Glaser - singing double / Judd's Girlfriend (voice)
- Brendan McCreary Ghost of Freddie Mercury (voice) / Freddie Mercury (singing voice)
-
Carlos Alazraqui
Gustavo (voice)
-
Julie Klausner
Cherry Marashina (voice)
-
Chris Redd
(voice)
-
Josie Totah
Natalie (voice)
-
Joel Kim Booster
Charles Lu (voice)
-
Judd Hirsch
Lewis Glouberman (voice)
-
Beck Bennett
Owen (voice)
-
Billy Porter
Ocean (voice)
- J Valerione B-High Qee-Choi Member (voice)
-
Keke Palmer
Rochelle the Hate Worm (voice)
-
Aidy Bryant
Emmy (voice)
-
Rosie Perez
Petra (voice)
-
Mitra Jouhari
-
Juliet Mills
-
Pamela Adlon
Sonya the Lovebug (voice)
-
Jon Hamm
Scallops (voice)
-
Jon Gabrus
Movie Theater Customer (voice)
-
Anna Graves
Mrs. Albert (voice)
-
Nasim Pedrad
Fatima (voice)
-
Mae Whitman
Tallulah Levine (voice)
- Chrissy Guerrero Choir Girl (voice)
-
Philip Quinaz
Tanya Alvarez (voice)
-
Harvey Fierstein
Older Guy Town Resident (voice)
-
Jerry Minor
Man #3 / Singing Fish (voice)
-
Piotr Michael
Siamese Twin #2 (voice)
- Marisa Lark Wallin Reese's Wertherspoon / Woman (voice)
-
Martin Short
Gordie (voice)
-
David Cross
Skip Glouberman (voice)
-
Carol Kane
Menopause Banshee / Old Woman (voice)
-
Tawny Newsome
(voice)
-
Retta
Duke's Mother (voice)
-
Wanda Sykes
Ghost of Harriet Tubman (voice)
-
Jaboukie Young-White
(voice)
-
Rob Riggle
Sgt. Adderall (voice)
-
Bobby Berk
Bobby Berk (voice)
-
Karamo Brown
Karamo Brown (voice)
-
Tan France
Tan France (voice)
-
Antoni Porowski
Antoni Porowski (voice)
-
Jonathan Van Ness
Jonathan Van Ness (voice)
-
Anna Konkle
Izzy (voice)
-
Maya Erskine
Misha (voice)
-
Alia Shawkat
Roland (voice)
-
Paul Giamatti
Andrew’s Shit (voice)
-
Adam Scott
Mr. Dylan Keating (voice)
-
Hugh Jackman
himself (voice)
-
Kumail Nanjiani
himself (voice)
-
Jemaine Clement
Simon Sex (voice)
-
Kristen Schaal
Bernie Sanders (voice)
-
Somali Rose
Missy’s Overalls
-
Lupita Nyong'o
Asha (voice)
-
Miranda Tapsell
Kara (voice)
-
Lin-Manuel Miranda
Puerto Rican Pubic Hair (voice)
-
Randall Park
Pete Doheny (voice)
-
Maitreyi Ramakrishnan
Marissa (voice)
-
Ava Lalezarzadeh
Nazanin (voice)
-
Don Cheadle
Don Cheadle (voice)
-
Padma Lakshmi
Priya (voice)
-
Zach Galifianakis
Gratitoad (voice)
-
Jeff Goldblum
The Apple Brooch
-
Steve Buscemi
-
Skyla I'Lece
- Katie Kreshek
- Violet Rivers
-
Larry Owens
-
Holly Hunter
-
James III
- Franny London
-
Cynthia Erivo
-
Andrew Goldberg
-
Eliseo Román
Eliseo Román (voice)
