cast
- Mister Lobo Mr. Lobo
- Dixie Dellamorto Ro-Mana / Babs from the Front Desk / Kogarella / Mumsy / Babbock/Ro-Mana/Lips / Unregistered Nurse #1 / Bat-Babs from the Front Desk / Unregistered Nurse / Post Apocalyptic Girl / Stacey's Mom / Ro-Mana/Mumsy / Mr. Lobo's assistant / St. Peter Cottontail / Miss Blobfest / Reel 7 Girl Applicant / Self
- Jessie Seeherman Countess Bloodsugar / Self / Nurse Wretched / Schoolgirl from Another Place / Lisabelle Jo-Bob Baby Doll Imperial JJ Walker Junior / Reel 7 Girl Applicant / Reel 7 Girl / Cosmonauti-74
- Sara Dunn Queen of Trash / Sheega!
- Aaron M. Lane Self / The Harbinger / The Harbinger (voice) / El Santo / Producer Aaron (voice) / Aaron
- John Stanley Self
- Roxanne Guarino That Horsemilken Gal / Anya / Gail Withers-Johnson / Carol Channing / Nexeter
- Crystal Quin Aunt Oddrey / Commander Micronauti / Self
- Larry Lee Moniz Larry Servo / Larry Servo/Joel
- Mike Neider Skinner / Prime-8 / Bigfoot's Neighbor
- Kristie Fenyoe Salon Receptionist / Naughty Nurse Batty / Astra Naughty / Special Appearance By
- Nicole M. King Sally the Zombie Cheerleader / Dr. Sphincter
- Nick Fenske Insomniac Theater Announcer / Insomniac Theater Narrator / Announcer
- Stephanie Hyden Cosmonaughti Prime / Cosmonauti Prime / Astro Naughty
- Marjorie Chardem Reel 7 Usher / Usherette / Candy Graves
- Elle Cornejo Reel 7 Girl / Post Apocalyptic Girl
- Chuck Francisco Dash Darling
-
Bob Wilkins
Self (archival footage)
- Derek Lobo Young Mister Lobo / 74 the Autobot / Robot 74
- Gary Hughes Commando Cody
- Karn Ford Ghost
- Tony Jackson Stage Hand
- Strephon Taylor Slob Zombie
- Summer Hairabedian Self / Reel 7 Girl
- J.C. Webster Self
- Chris Gill Soldier / The Wraith
- Jason Patrick The Phantom / Star Stalker
- Cola Waller The Hand / Lil' Kimmisan
-
Keith Lowell Jensen
Francois Fly
- Danger Pussy Lady Skankenstein
-
Melissa LaMartina
Aurora Gorealis
- Donald David Teenage Prince of Mars / The King of Mars
- Alex Doll Miss Blobfest / Ms. Blobfest 2018
- Amanda Teach-Wolfe Unregistered Nurse / Unregistered Nurse #2
- Mark Hyman Rad Abrams
- J. Ryan Hickey The Shape / Dollar Store Jason
- Shannon McCabe Self / Reel 7 Vampire
- Ron Dante Self
- Joseph Herb Mr. Lobo's Dad / Blind Pizza Guy
- Amanda Sorrento Zuzu / Velma
- Amber Kloss Reel 7 Girl / Nurse
- John Dimes Professor Ex-Exorcist / Rick Furry
- Rich Koz Self / Dr. Rummage Goodwill (voice)
-
Shadoe Stevens
OSI Announcer (voice) / OSI Announcer
- Joe LaScola Gernie Gonax / Francois Fly
- Wendy Sews Death / Punkin Ghoul/Emperor Maus
- Anthony Corten Self
- Joseph Torres Hudson J. Beardo
- Tim Caldwell Self
- Nigel Honeybone Self
- Martin Ramsdin Self
- Steven R. Campbell Self
- Monica Moehring Babs Valentine (voice)
- Allen Carnahan Louisiana Klingon K'allen
- Shane Dyson Louisiana Klingon Ri'Par
-
Richard Hatch
Self
- Dale Long Gold Cylon
- Brian Walsh Gigantis
-
Chase Masterson
Self
-
Cassandra Peterson
Self
- Akili Jones Ben
- Eric Miller Self
- Don Drakulich Dean Slithers
- Kieth Almoney Self
- Joan Homick Dr. Ima Hack
- Roxanne Kateri Daphne
- Christopher R. Mihm Self
- Kevin Rice Creighton
- Frank Stone Dr. Frank N. Stone
- Kris Yeaworth Self
- Emily Manka-White Jennifer Carnally
- Bethany Hidden-Cauley Last Woman On Earth
- Wendy Ho Last Woman on Earth
- McKenna Howell Last Woman on Earth
- Erica Lynn Last Woman on Earth
- Rachel Nordman Last Woman on Earth
- Heather Taylor Last Woman on Earth
- Megan Fanta Yee Last Woman on Earth
- Carl Dubbeling John Stanley
- Laura Owens Admiral Holdout
- Newt Wallen Herbie
- Alan Fernandes Self
- C. Andrew Nelson Self
- Candy Graves Lurg
- Suzanne Firner Miss Blobfest 2019
-
Joel Hodgson
Self
-
Marta Kristen
Self
- Rudy Lucente Organist
-
Matt McGinnis
Self
-
Mark Allan Stewart
Self
- Chris Grill The Alien
- Scott Bradley The Creature
- Spencer Smith Delinquent
-
Dave Attell
Self
-
Sid Haig
Self
-
Richard Dyszel
Sheriff Bronson Canyon
- Andrea Marie Lady Chestburster
- Jerry Moore Vinny Price Tagge
- Ali Noel Tangella
- Räven Green Livingston
- Bob Moricz Doctor Loco
-
Irwin Keyes
Self
- Samm Todd Self
- Paul Sanders Self
- Rae Evanssen Miss Horror Film 2003
- Jake Corbin Kid
- Phil E. Peirson Doctor Greene
- Joshua Kennedy Self
- John Huff Self
- Lee Demarbre Self
-
G. Larry Butler
Dr. Lazaroff
- Cayce Campaign Blair
- Vivi Courtois Junior Lobo Cub
- Virgil Cardamone Self
- Charles Chiodo Self
- Edward Chiodo Self
-
Stephen Chiodo
Self
-
Conrad Brooks
Self
-
Ernie Fosselius
Self
-
Eileen Dietz
Self
-
Kathleen Kinmont
Self
- Jim Krut Self
-
Nancy Kyes
Self
- Darryl Rabideau Self
-
Ted Raimi
Self
- Gerald Reilley Self
-
Kyra Schon
Self
-
Vernon Wells
Self
-
Caroline Williams
Self
- Pepper Alexandria Self
- Sara Dunn Cosmilina: Six of Nine
- David Malikkal Shorty Lobo
- August Ragone Self
- Shane Stone Dr. Frank N. Stone
-
Terry Kiser
Self
-
Bob Budiansky
Self
- Tim Clarke Self
- David Kyle Eisenhauer Self
- Peri Fisher She-Hulk
-
Larry Kenney
Self
- Laura DuPriest Bigfoot's Hair & Make-Up
- Scott Moon Bigfoot's Roommate
- Beatrix Troutman Mini Sally the Zombie Cheerleader
- Sean Jordan Self
-
Renae Jacobs
Self